墨尔本的研究人员在培植与人体非常相似的血液干细胞方面取得了世界上第一个突破。

Melbourne researchers have made a world first breakthrough into creating blood stem cells that closely resemble those in the human body.

这项研究由默多克儿童研究所(MCRI)领导，并发表在《自然--生物技术》(Nature Biotechnology)杂志上。该研究培育的人类血液干细胞可以产生与人类胚胎中非常相似的红细胞、白细胞和血小板。

The research, led by Murdoch Children's Research Institute (MCRI) and published in Nature Biotechnology, has overcome a major hurdle for producing human blood stem cells, which can create red cells, white blood cells and platelets, that closely match those in the human embryo.

该重大发现为实验室培养用于血液干细胞和骨髓移植的干细胞铺平了道路。

This significant discovery in human blood stem cell development paves the way for these lab grown cells to be used in blood stem cell and bone marrow transplants.

她说:“从病人身上提取任何细胞，将其重新编程为干细胞，然后将其转化为与移植特别匹配的血细胞，这种能力将对这些脆弱病人的生命产生巨大影响。”

"The ability to take any cell from a patient, reprogram it into a stem cell and then turn these into specifically matched blood cells for transplantation will have a massive impact on these vulnerable patients' lives," she said.

重要的是，这些人类细胞可以以临床使用所需的规模和纯度被培育出来。

Importantly, these human cells can be created at the scale and purity required for clinical use.

在这项研究中，免疫缺陷小鼠移植了实验室改造的人类血液干细胞。

In the study, immune deficient mice were injected with the lab engineered human blood stem cells.

研究发现，造血干细胞变成具有功能的骨髓，其水平与脐带血细胞移植中看到的水平相似。

It found the blood stem cells became functional bone marrow at similar levels to that seen in umbilical cord blood cell transplants.

MCRI教授埃德·斯坦利(Ed Stanley)表示，这一发现可能会为一系列血液疾病带来新的治疗选择。

MCRI Professor Ed Stanley said the findings could lead to new treatment options for a range of blood disorders.

Elefanty教授说，下一阶段可能在五年内，在政府资助下进行一期临床试验，以测试在人体内使用这些实验室培养的血细胞的安全性。

Professor Elefanty said the next stage, likely in about five years with government funding, would be conducting a phase one clinical trial to test the safety of using these lab grown blood cells in humans.

Journal Reference:

Elizabeth S. Ng, Gulcan Sarila, Jacky Y. Li, Hasindu S. Edirisinghe, Ritika Saxena, Shicheng Sun, Freya F. Bruveris, Tanya Labonne, Nerida Sleebs, Alexander Maytum, Raymond Y. Yow, Chantelle Inguanti, Ali Motazedian, Vincenzo Calvanese, Sandra Capellera-Garcia, Feiyang Ma, Hieu T. Nim, Mirana Ramialison, Constanze Bonifer, Hanna K. A. Mikkola, Edouard G. Stanley, Andrew G. Elefanty. Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells. Nature Biotechnology, 2024; DOI: 10.1038/s41587-024-02360-7