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13.45亿元!三优生物祝贺明慧医药B7-H3 ADC药物MHB088C挺进III期临床,与齐鲁制药达成重磅战略合作

B7-H3 联药
5小时前
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近日,由三优生物提供抗体药研发CPO,明慧医药研发创新的B7-H3靶向抗体偶联药物MHB088C已正式在中国启动针对难治性小细胞肺癌(SCLC)的III期注册临床试验(CTR20250586)。同时,明慧医药与齐鲁制药就MHB088C达成总额13.45亿元人民币的独家授权合作,创下中国ADC领域又一里程碑!

MHB088C是明慧基于自主研发的SuperTopoi™ ADC技术平台打造的创新型B7-H3靶向抗体偶联药物,兼具更强的肿瘤杀伤效力与更优的安全性,显著拓宽了治疗窗口。

三优生物有幸通过CPO业务模式助力明慧医药达成这一重要里程碑,协同明慧医药完成了临床前B7-H3抗体药物发现的关键工作。(更多三优ADC研发服务信息请阅读三优ADC药物研发系统解决方案)。


三优生物CEO郎国竣博士表示:

“我们由衷祝贺明慧医药MHB088C实现从科学概念到III期临床的飞跃,并达成与齐鲁制药的战略合作!期待这款中国创新的重磅ADC药物早日上市,为全球患者点燃生命新希望!”

关于明慧医药

明慧医药是一家处于临床后期阶段的生物制药公司,专注于开发创新药物,以满足肿瘤和自身免疫性疾病领域的未满足医疗需求。依托其专有技术平台,公司已构建多元化的临床阶段产品管线,包括创新型ADC项目和PD-1xVEGF双特异性抗体。明慧医药致力于推进突破性疗法,改善全球患者的治疗效果。

关于三优生物

三优生物是一家以“让天下没有难做的创新生物药”为使命,以超万亿分子库和人工智能技术双驱的生物医药智能高新技术企业。

公司以智能超万亿分子库为核心,打造了干湿结合、国际领先的创新生物药临床前智能化及一体化研发平台,通过“新药发现、临床前研究、智能化药物研发及前沿科学研究”等四个维度加速全球新药发现及靶标深度研究。

公司总部位于中国上海,在美国、欧洲等地设有子公司,现有投产及布局的研发及GMP场地20000多平方米。

公司为合作伙伴提供“差异化CRO、整合型CDO、协同型CPO、特色CRS”于一体的“创新生物药4C综合业务”。公司已建立全球营销网络,已与全球1200多家药企、生技公司等建立了良好的合作关系;已完成了1200多个新药发现及开发服务项目;已完成了50多个合作研发项目,其中9个合作项目已完成临床申报。

公司已获得国家高新技术、上海市专精特新、上海市小巨人和上海“张江之星”企业认定。


USD 187 million! Sanyou Biopharmaceuticals Congratulates Minghui Pharmaceutical on Advancing B7-H3 ADC Drug MHB088C to Phase III Clinical Trials and Reaching a Major Strategic Partnership with Qilu Pharmaceutical



Recently, MHB088C, a B7-H3 targeted antibody-coupled drug developed and innovated by Minghui Pharmaceuticals, with CPO provided by Sanyou Biopharmaceuticals for antibody drug development, has officially initiated a Phase III registered clinical trial (CTR20250586) in China for refractory small cell lung cancer (SCLC). Meanwhile, Minghui Pharma and Qilu Pharmaceutical entered into an exclusive license agreement totaling RMB 1.345 billion for MHB088C, marking another milestone in China's ADC field!

MHB088C is an innovative B7-H3-targeted ADC developed by Minghui Pharmaceutical using its proprietary SuperTopoi™ ADC platform. Structurally, the linker and payload of MHB088C are optimized versions of Daiichi Sankyo’s GGFG and DXd, with the payload showing 5–10 times the potency of DXd and a Drug-to-Antibody Ratio (DAR) of 4.

Sanyou Biopharmaceuticals was honored to support Minghui Pharmaceutical in reaching this milestone through its Collaborative Project Outsourcing (CPO) service model, assisting with critical preclinical antibody discovery efforts. (For more information about Sanyou’s ADC development services, please refer to the "Sanyou ADC Drug Development Systematic Solutions.")


Dr. Guojun Lang, CEO:

"We sincerely congratulate Minghui Pharmaceutical on the remarkable leap of MHB088C from scientific concept to Phase III clinical trials, and on achieving a strategic partnership with Qilu Pharmaceutical. We look forward to seeing this groundbreaking Chinese innovation become available to patients worldwide, igniting new hope for life!"

About Minghui Pharmaceutical

Minghui Pharmaceutical is a late-stage clinical biopharmaceutical company dedicated to developing innovative medicines to address unmet medical needs in oncology and autoimmune diseases. With expertise in medical science and proprietary technology platforms, the company has built a diverse clinical-stage pipeline, including novel ADC programs and a PD-1xVEGF bispecific antibody. Minghui is committed to advancing breakthrough therapies that improve patient outcomes worldwide.

About Sanyou Biopharmaceuticals

Sanyou Biopharmaceuticals is a cutting-edge antibody drug discovery and development company, featured by its super-trillion antibody library and its capability of both AI and wet-lab R&D platforms, with the mission of “making innovative biologics R&D easy for clients worldwide.”

Focusing on its intelligent super-trillion antibody library, Sanyou has built a world-leading, integrated and intelligent R&D platform for preclinical development of innovative biologics that seamlessly combines in silico and wet-lab capabilities. The company accelerates global new drug discovery and target research through four dimensions: new drug discovery, preclinical research, AI-driven drug development, and frontier scientific research.

Headquartered in Shanghai, China, Sanyou has subsidiaries in the United States, Europe, and other regions, with over 20,000 square meters of R&D and GMP-compliant facilities in operation or under development.

Sanyou offers its clients and partners a comprehensive "4C" service solution set that includes CRO, CDO, CPO (Collaborative Project Organization), and CRS (Core Reagent Solution) services. The company has established a global marketing network and formed strong partnerships with more than 1,200 pharmaceutical and biotech companies worldwide. It has successfully completed over 1,200 projects related to new drug discovery and development, more than 50 collaborative R&D projects, with 9 projects having completed IND submission.

Sanyou has been recognized as a National High-tech Enterprise, a Shanghai "Specialized and Innovative" Enterprise, a Shanghai "Little Giant" Enterprise, and a "Zhangjiang Star" Enterprise in Shanghai.


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